Children Exposed to Chemotherapy In Utero

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Children exposed to chemotherapy in utero.

The majority of the information on the effects of in utero exposure to chemotherapy has been derived from retrospective case reports and series. Overviews of the available data have concluded that the timing of chemotherapy exposure (first trimester versus second and third trimesters) as well as the chemotherapeutic agent or agents used affect the risk of spontaneous abortion and miscarriage as...

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OBJECTIVE The purpose of this study is to determine the frequency of emotional, behavioral, and learning disorders in children exposed in utero to hyperemesis gravidarum (HG) and to identify prognostic factors for these disorders. STUDY DESIGN Neurodevelopmental outcomes of 312 children from 203 mothers with HG were compared to neurodevelopmental outcomes from 169 children from 89 unaffected ...

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Intellectual impairment in children exposed to polychlorinated biphenyls in utero.

BACKGROUND In utero exposure to polychlorinated biphenyls, a ubiquitous environmental contaminant, has been linked to adverse effects on neurologic and intellectual function in infants and young children. We assessed whether these effects persist through school age and examined their importance in the acquisition of reading and arithmetic skills. METHODS We tested 212 children, recruited as n...

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Neurodevelopment of adopted children exposed in utero to cocaine.

OBJECTIVE To assess the neurodevelopment of adopted children who had been exposed in utero to cocaine. DESIGN A case-control observational study. PARTICIPANTS Twenty-three children aged 14 months to 6.5 years exposed in utero to cocaine and their adoptive mothers, and 23 age-matched control children not exposed to cocaine and their mothers, matched with the adoptive mothers for IQ and socio...

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BACKGROUND The use of cyclosporin (CsA) has improved graft survival in transplant (Tx) patients despite its potential nephrotoxicity. Children born to transplanted women may present with intrauterine growth retardation (IUGR). On the basis of potential reduced nephron mass both in IUGR and in newborn experimental animals exposed to CsA in utero, we investigated the renal function of children >1...

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ژورنال

عنوان ژورنال: Journal of the National Cancer Institute Monographs

سال: 2005

ISSN: 1052-6773

DOI: 10.1093/jncimonographs/lgi009